2. Academic Validation
  3. Biotin labelling of amines by polymer-assisted solution-phase synthesis

Biotin labelling of amines by polymer-assisted solution-phase synthesis

  • Bioorg Med Chem Lett. 2001 Jul 9;11(13):1783-6. doi: 10.1016/s0960-894x(01)00296-7.
A Golisade 1,  C Herforth,  K Wieking,  C Kunick,  A Link
Affiliations

Affiliation

  • 1 Universität Hamburg, Institut für Pharmazie, Bundesstrasse 45, D-20146, Hamburg, Germany.
PMID: 11425560 DOI: 10.1016/s0960-894x(01)00296-7
Abstract

An efficient and simple polymer-assisted approach has been developed to biotinylate multifunctional compounds bearing an amino functionality. Biotin was immobilized on aminomethylated polystyrene via the Kenner safety catch linker, activated and subsequently transferred to the amino function of the target compounds chemoselectively, thus avoiding protecting group operations. This approach holds potential for the introduction of spacer-modified biotin derivatives.

Figures
Products