2. Academic Validation
  3. Aurantiamide acetate, a selective cathepsin inhibitor, produced by Aspergillus penicilloides

Aurantiamide acetate, a selective cathepsin inhibitor, produced by Aspergillus penicilloides

  • Biosci Biotechnol Biochem. 2001 May;65(5):1195-7. doi: 10.1271/bbb.65.1195.
K Isshiki 1,  Y Asai,  S Tanaka,  M Nishio,  T Uchida,  T Okuda,  S Komatsubara,  N Sakurai
Affiliations

Affiliation

  • 1 Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
PMID: 11440138 DOI: 10.1271/bbb.65.1195
Abstract

Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate inhibited cysteine proteinases, in particular, Cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.

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