2. Academic Validation
  3. Novel cytotoxic annonaceous acetogenins from Annona muricata

Novel cytotoxic annonaceous acetogenins from Annona muricata

  • J Nat Prod. 2001 Jul;64(7):925-31. doi: 10.1021/np010035s.
F R Chang 1,  Y C Wu
Affiliations

Affiliation

  • 1 Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PMID: 11473425 DOI: 10.1021/np010035s
Abstract

Seven new annonaceous acetogenins, muricins A-G (1-7), as well as five known compounds, a mixture of muricatetrocin A (8) and muricatetrocin B (9), longifolicin (10), corossolin (11), and corossolone (12), were isolated from the seeds of Annona muricata. The structures of all isolates were elucidated and characterized by spectral and chemical methods. These acetogenins showed significantly selective in vitro cytotoxicities toward the human hepatoma cell lines Hep G(2) and 2,2,15.

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