2. Academic Validation
  3. A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives

A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives

  • Bioorg Med Chem Lett. 2001 Sep 3;11(17):2361-3. doi: 10.1016/s0960-894x(01)00429-2.
G Fan 1,  W Mar,  M K Park,  E W Choi,  K Kim,  S Kim
Affiliations

Affiliation

  • 1 Natural Products Research Institute, Seoul National University, 28 Yungun, Jongro, Seoul 110-460, South Korea.
PMID: 11527731 DOI: 10.1016/s0960-894x(01)00429-2
Abstract

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in Cell Culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

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