2. Academic Validation
  3. Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists

Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists

  • Bioorg Med Chem Lett. 2001 Oct 8;11(19):2663-6. doi: 10.1016/s0960-894x(01)00530-3.
Y Yoneda 1,  S Kawajiri,  M Sugimura,  K Osanai,  F Kito,  E Ota,  T Mimura
Affiliations

Affiliation

  • 1 Medicinal Chemistry Research Laboratory, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. yoned10z@diichipharm.co.jp
PMID: 11551773 DOI: 10.1016/s0960-894x(01)00530-3
Abstract

We synthesized diaminobutane derivatives as potent CA(2+)-permeable AMPA Receptor antagonists with non-hypotensive activity. Compound 10c showed selective CA(2+)-permeable AMPA Receptor Antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.

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