2. Academic Validation
  3. Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes

Direct comparison of the potency of three novel cAMP analogs to induce CREB-phophorylation in rat pinealocytes

  • J Pineal Res. 2001 Sep;31(2):183-5. doi: 10.1034/j.1600-079x.2001.310214.x.
E Maronde 1,  H W Korf,  P Niemann,  H G Genieser
Affiliations

Affiliation

  • 1 Dr. Senckenbergische Anatomie, Anatomisches Institut II, J.W. Goethe Universität, Frankfurt, Germany. emaronde@web.de
PMID: 11555176 DOI: 10.1034/j.1600-079x.2001.310214.x
Abstract

A modified analog of cyclic adenosine 3',5'-monophosphate (cAMP), Sp-adenosine-3',5'-monophosphorothioate, designed to be highly membrane-permeable and resistant towards phosphodiesterases was found to induce the phosphorylation of the cAMP-regulated transcription factor cyclic AMP-responsive element binding protein in cultured rat pinealocytes more efficiently than previously described cAMP analogs.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-137624
    PKA Activator
    PKA