2. Academic Validation
  3. Indole and beta-carboline alkaloids from Geissospermum sericeum

Indole and beta-carboline alkaloids from Geissospermum sericeum

  • J Nat Prod. 2002 Jan;65(1):85-8. doi: 10.1021/np0101705.
Jonathan C P Steele 1,  Nigel C Veitch,  Geoffrey C Kite,  Monique S J Simmonds,  David C Warhurst
Affiliations

Affiliation

  • 1 Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, TW9 3DS, UK.
PMID: 11809075 DOI: 10.1021/np0101705
Abstract

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.

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