Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris

J Nat Prod. 2002 Feb;65(2):95-9. doi: 10.1021/np010459m.

Nicholas H Oberlies ¹, Jason P Burgess, Hernán A Navarro, Rosa Elena Pinos, Craig R Fairchild, Russell W Peterson, Djaja D Soejarto, Norman R Farnsworth, A Douglas Kinghorn, Mansukh C Wani, Monroe E Wall

Affiliations

Affiliation

1 Chemistry and Life Sciences, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.

PMID: 11858737 DOI: 10.1021/np010459m

Abstract

Fractionation of a methanol extract of the leaves and twigs of Casearia sylvestris, as directed by activity against KB cell cytotoxicity, led to the isolation of three novel clerodane Diterpenoids, casearvestrins A-C (1-3). The structures of 1-3 were deduced from one- and two-dimensional NMR experiments, including relative stereochemical assignments based on ROESY correlations and COSY coupling constants. All three compounds displayed promising bioactivity, both in cytotoxicity assays against a panel of tumor cell lines and in Antifungal assays via the growth inhibition of Aspergillus niger in a disk diffusion assay.

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