2. Academic Validation
  3. Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

Pseudoirroratin A, a new cytotoxic ent-kaurene diterpene from Isodon pseudo-irrorata

  • J Nat Prod. 2002 Feb;65(2):215-7. doi: 10.1021/np010420h.
Hongjie Zhang 1,  Zhuting Fan,  Ghee T Tan,  Hee-Byung Chai,  John M Pezzuto,  Handong Sun,  Harry H S Fong
Affiliations

Affiliation

  • 1 Program for Collaborative Research in Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
PMID: 11858760 DOI: 10.1021/np010420h
Abstract

A new ent-kaurene diterpene, pseudoirroratin A (1), and a known diterpene, pseurata A, were isolated from Isodon pseudo-irrorata. Compound 1 showed significant cytotoxicity against the Lu1, SW626, LNCaP, KB, and HOS Cancer cell lines with IC(50) values of 0.26 (0.75), 0.20 (0.57), 0.90 (2.59), 0.90 (2.59), and 0.50 (1.44) microg/mL (microM), respectively. The structure of 1 was elucidated by spectroscopic means including 1D and 2D NMR techniques.

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