2. Academic Validation
  3. Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor

Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor

  • Bioorg Med Chem Lett. 2002 Mar 11;12(5):779-82. doi: 10.1016/s0960-894x(02)00013-6.
Sabine Barbey 1,  Laurence Goossens,  Thierry Taverne,  Joséphine Cornet,  Valérie Choesmel,  Céline Rouaud,  Gilles Gimeno,  Sylvie Yannic-Arnoult,  Catherine Michaux,  Caroline Charlier,  Raymond Houssin,  Jean Pierre Hénichart
Affiliations

Affiliation

  • 1 Laboratoires Innothera, avenue P. Vaillant-Couturier, BP 10, 94110, Arcueil, France.
PMID: 11859001 DOI: 10.1016/s0960-894x(02)00013-6
Abstract

Dual COX-2/5-LO inhibitors are described as potential new therapeutic agents for inflammatory diseases. A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.

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