Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4

Nat Immunol. 2002 Mar;3(3):237-43. doi: 10.1038/ni760.

C C Chang ¹, R Ciubotariu, J S Manavalan, J Yuan, A I Colovai, F Piazza, S Lederman, M Colonna, R Cortesini, R Dalla-Favera, N Suciu-Foca

Affiliations

Affiliation

1 Department of Pathology, Columbia University, New York, NY 10032, USA.

PMID: 11875462 DOI: 10.1038/ni760

Abstract

Immunoglobulin-like transcript 3 (ILT3) and ILT4 belong to a family of inhibitory receptors expressed by human monocytes and dendritic cells. We show here that CD8+CD28(-) alloantigen-specific T suppressor (TS) cells induce the up-regulation of ILT3 and ILT4 on monocytes and dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic. Tolerogenic APCs show reduced expression of costimulatory molecules and induce antigen-specific unresponsiveness in CD4+ T helper cells. Studies of human heart transplant recipients showed that rejection-free patients have circulating TS cells, which induce the up-regulation of ILT3 and ILT4 in donor APCs. These findings demonstrate an important mechanism of immune regulation.

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