2. Academic Validation
  3. CJ-21,058, a new SecA inhibitor isolated from a fungus

CJ-21,058, a new SecA inhibitor isolated from a fungus

  • J Antibiot (Tokyo). 2002 Jan;55(1):25-9. doi: 10.7164/antibiotics.55.25.
Yutaka Sugie 1,  Sae Inagaki,  Yoshinao Kato,  Hiroyuki Nishida,  Chang-Hong Pang,  Toshiyuki Saito,  Shinichi Sakemi,  Fadia Dib-Hajj,  John P Mueller,  Joyce Sutcliffe,  Yasuhiro Kojima
Affiliations

Affiliation

  • 1 Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals, Inc., Aichi, Japan. Yutaka.Sugie@japan.pfizer.com
PMID: 11918061 DOI: 10.7164/antibiotics.55.25
Abstract

A new equisetin derivative, CJ-21,058 (I) was isolated from the fermentation broth of an unidentified fungus CL47745. It shows Antibacterial activity against Gram-positive multi-drug resistant bacteria by inhibiting ATP-dependent translocation of precursor proteins across a Bacterial cell membrane.

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