CJ-21,058

Cat. No.: HY-N7188: FAQs
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CJ-21,058 is a potent SecA inhibitor with an IC₅₀ value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria.

For research use only. We do not sell to patients.

CJ-21,058 Chemical Structure

CAS No. : 405072-57-3

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Description	CJ-21,058 is a potent SecA inhibitor with an IC₅₀ value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria^[1].
IC₅₀ & Target	IC₅₀: 15 µg/mL (SecA)^[1]
In Vitro	CJ-21,058 (0-20 µg/mL) shows antibacterial activity with MIC values of 5, >20, 5, >20 µg/mL for Staphylococcus aureus 01A1105, Streptococcus pyogenes 02C1068, Enterococcus faecalis 03A1069, Escherichia coli 51A0266, respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. CJ-21,058 Related Antibodies
Molecular Weight	387.51
Formula	C₂₃H₃₃NO₄
CAS No.	405072-57-3
SMILES	O/C([C@@]([C@@](CC[C@H]1C)([H])[C@](C1)([H])C=C2C)([C@@H]2/C=C/C)C)=C(C(N3C)=O)\C([C@@H]3CO)=O
Structure Classification	Others
Initial Source	Microorganisms fungus CL47745
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Sugie Y, et al. CJ-21,058, a new SecA inhibitor isolated from a fungus. J Antibiot (Tokyo). 2002 Jan;55(1):25-9. [Content Brief]

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Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CJ-21,058405072-57-3BacterialATP-dependentantibacterialStaphylococcus aureusEnterococcus faecalisInhibitorinhibitorinhibit

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CJ-21,058

CJ-21,058 Related Antibodies

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