2. Academic Validation
  3. Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

  • Bioorg Med Chem Lett. 2002 May 20;12(10):1347-9. doi: 10.1016/s0960-894x(02)00175-0.
Shinichi Uesato 1,  Manabu Kitagawa,  Yasuo Nagaoka,  Taishi Maeda,  Hiroshi Kuwajima,  Takao Yamori
Affiliations

Affiliation

  • 1 Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, 564-8680, Osaka, Japan. uesato@ipicku.kansai-u.ac.jp
PMID: 11992774 DOI: 10.1016/s0960-894x(02)00175-0
Abstract

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.

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