2. Academic Validation
  3. Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

  • Bioorg Med Chem Lett. 2002 Jun 17;12(12):1675-7. doi: 10.1016/s0960-894x(02)00232-9.
L Roberto Martínez 1,  Jose Gustavo Avila Zarraga,  Ma Esther Duran,  Ma Teresa Ramírez Apam,  Roberto Cañas
Affiliations

Affiliation

  • 1 Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacán, México, D.F., Mexico. robmar@servidor.unam.mx
PMID: 12039588 DOI: 10.1016/s0960-894x(02)00232-9
Abstract

We report the regio- and stereoselective synthesis of a novel cis-C(3)N-C(4)X-C(6)N series (X=O, S, and C(2)) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.

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