2. Academic Validation
  3. Synthesis and characterization of pregabalin lactose conjugate degradation products

Synthesis and characterization of pregabalin lactose conjugate degradation products

  • J Pharm Biomed Anal. 2002 Jun 1;28(5):917-24. doi: 10.1016/s0731-7085(01)00710-5.
Michael J Lovdahl 1,  Timothy R Hurley,  Brian Tobias,  Stephen R Priebe
Affiliations

Affiliation

  • 1 Analytical Development Department, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. michael.lovdahl@pfizer.com
PMID: 12039634 DOI: 10.1016/s0731-7085(01)00710-5
Abstract

Seven degradation products observed in formulated pregabalin have been characterized. These compounds result from Maillard reactions and Amadori rearrangements. Heating pregabalin in the presence of lactose formed significant quantities of these degradation products. The seven compounds corresponding to the observed degradation products were isolated by preparative liquid chromatography. The synthesis, isolation, and spectral characterization of the degradation products are detailed.

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