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  3. A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues

A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues

  • Org Lett. 2002 Jun 13;4(12):2091-3. doi: 10.1021/ol020073i.
T G Murali Dhar 1,  Junqing Guo,  Zhongqi Shen,  William J Pitts,  Henry H Gu,  Bang-Chi Chen,  Rulin Zhao,  Mark S Bednarz,  Edwin J Iwanowicz
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA. dharm@bms.com
PMID: 12049525 DOI: 10.1021/ol020073i
Abstract

[structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described.

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