2. Academic Validation
  3. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model

In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model

  • Antimicrob Agents Chemother. 2002 Jul;46(7):2310-2. doi: 10.1128/AAC.46.7.2310-2312.2002.
Qiu N Sun 1,  Laura K Najvar,  Rosie Bocanegra,  David Loebenberg,  John R Graybill
Affiliations

Affiliation

  • 1 Division of Infectious Disease, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA.
PMID: 12069997 DOI: 10.1128/AAC.46.7.2310-2312.2002
Abstract

The in vivo activities of posaconazole, itraconazole, and amphotericin B in neutropenic mice with zygomycosis were compared. The in vitro MICs of posaconazole and itraconazole for the strains of Mucor spp. used in this study ranged from 0.125 to 8 microg/ml and 0.25 to 8 microg/ml, respectively. The in vitro MIC range for amphotericin B is 0.125 to 0.25 microg/ml. At twice-daily doses of >or=15 mg/kg of body weight, posaconazole prolonged the survival of the mice and reduced tissue burden.

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