2. Academic Validation
  3. Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis

Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis

  • J Immunol. 2002 Jul 15;169(2):642-6. doi: 10.4049/jimmunol.169.2.642.
Trevor Starnes 1,  Hal E Broxmeyer,  Michael J Robertson,  Robert Hromas
Affiliations

Affiliation

  • 1 Department of Medicine, Walther Oncology Center, Indiana University Medical Center, Indianapolis, IN 46202, USA.
PMID: 12097364 DOI: 10.4049/jimmunol.169.2.642
Abstract

A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-kappa B-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.

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