2. Academic Validation
  3. Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis

Ancistrocongolines A-D, new naphthylisoquinoline alkaloids from ancistrocladus congolensis

  • J Nat Prod. 2002 Aug;65(8):1096-101. doi: 10.1021/np010622d.
Gerhard Bringmann 1,  Kim Messer,  Reto Brun,  Virima Mudogo
Affiliations

Affiliation

  • 1 Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
PMID: 12193010 DOI: 10.1021/np010622d
Abstract

Four new naphthylisoquinoline Alkaloids, ancistrocongolines A-D (4-7) were isolated from Ancistrocladus congolensis, along with the known compound korupensamine A (8). Structural elucidation was achieved by chemical, spectroscopic, and chiroptical methods. Their biological activities against the pathogens of malaria, Leishmaniasis, Chagas disease, and African sleeping sickness were evaluated.

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