2. Academic Validation
  3. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo

  • Infect Immun. 2002 Dec;70(12):7136-9. doi: 10.1128/IAI.70.12.7136-7139.2002.
Miroslav S Sarac 1,  Angus Cameron,  Iris Lindberg
Affiliations

Affiliation

  • 1 Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans 70112, USA.
PMID: 12438396 DOI: 10.1128/IAI.70.12.7136-7139.2002
Abstract

The Pseudomonas aeruginosa exotoxin A (PEA) protein requires furin-mediated cleavage for manifestation of toxicity. We show here that the small stable Furin Inhibitor hexa-D-arginine amide effectively blocks PEA-induced Cell Lysis and is itself noncytotoxic. Administration of hexa-D-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha.

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