2. Academic Validation
  3. IL-28, IL-29 and their class II cytokine receptor IL-28R

IL-28, IL-29 and their class II cytokine receptor IL-28R

  • Nat Immunol. 2003 Jan;4(1):63-8. doi: 10.1038/ni873.
Paul Sheppard 1,  Wayne Kindsvogel,  Wenfeng Xu,  Katherine Henderson,  Stacy Schlutsmeyer,  Theodore E Whitmore,  Rolf Kuestner,  Ursula Garrigues,  Carl Birks,  Jenny Roraback,  Craig Ostrander,  Dennis Dong,  Jinu Shin,  Scott Presnell,  Brian Fox,  Betty Haldeman,  Emily Cooper,  David Taft,  Teresa Gilbert,  Francis J Grant,  Monica Tackett,  William Krivan,  Gary McKnight,  Chris Clegg,  Don Foster,  Kevin M Klucher
Affiliations

Affiliation

  • 1 ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, WA 98102, USA.
PMID: 12469119 DOI: 10.1038/ni873
Abstract

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral Infection and showed Antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 Receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral Infection.

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