2. Academic Validation
  3. Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl

Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl

  • Biochem J. 2003 Feb 15;370(Pt 1):29-34. doi: 10.1042/BJ20021539.
Philippe Soubeyran 1,  Ana Barac,  Iwona Szymkiewicz,  Ivan Dikic
Affiliations

Affiliation

  • 1 Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S-75124, Sweden.
PMID: 12475393 DOI: 10.1042/BJ20021539
Abstract

The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin Ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.

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