2. Academic Validation
  3. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa

Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa

  • Planta Med. 2002 Dec;68(12):1131-3. doi: 10.1055/s-2002-36358.
Jeong Suk Ko 1,  Mun-Chual Rho,  Mi Yeon Chung,  Hye Young Song,  Jong Seong Kang,  Koanhoi Kim,  Hyun Sun Lee,  Young Kook Kim
Affiliations

Affiliation

  • 1 Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea.
PMID: 12494344 DOI: 10.1055/s-2002-36358
Abstract

From the diacylglycerol Acyltransferase (DGAT) activity-guided fractionation, a new Quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone Alkaloids, evocarpine (2), 1-methyl-2-[(4 Z,7 Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6 Z,9 Z)-6,9-pentadecadienyl]-4(1 H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC 50 values of 69.5 microM ( 1), 23.8 microM (2), 20.1 microM (3) and 13.5 mu (4).

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