1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat. No.: HY-N9530: FAQs
Data Sheet Handling Instructions

Molarity Calculator

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL.

For research use only. We do not sell to patients.

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone Chemical Structure

CAS No. : 120693-53-0

Size	Stock
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Acyltransferase Isoform Specific Products:

View All Isoforms

ACAT1 ACAT2 MGAT2 ACAT

View All Angiotensin Receptor Isoform Specific Products:

View All Isoforms

AT1 Receptor AT2 Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL^[1]^[2]^[3].
IC₅₀ & Target	IC50: 20.1 μM (diacylglycerol acyltransferase)^[3], 34.1 μM (angiotensin II receptor)^[2]
In Vitro	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows anti-Helicobacter pylori activity, with the MIC of 10 μg/mL, and has no effect on Helicobacter pylori urease activity at the concentration of 300 μg/mL^[1]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-500 μM) shows a dose-dependent diacylglycerol acyltransferase (DGAT) inhibition, with an IC₅₀ of 20.1 μM^[3]. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (5-20 μM) inhibits leukotriene biosynthesis in human polymorphonuclear granulocytes, with an IC₅₀ of 10.1 μM^[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone Related Antibodies
Molecular Weight	337.50
Formula	C₂₃H₃₁NO
CAS No.	120693-53-0
SMILES	CN1C2=CC=CC=C2C(C=C1CCC/C=C\C/C=C\CCCCC)=O
Structure Classification	Alkaloids Quinoline Alkaloids
Initial Source	Plants Rutaceae Evodia rutaecarpa (Juss.) Benth.
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Rho TC, et, al. Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus. Biol Pharm Bull. 1999 Oct;22(10):1141-3. [Content Brief] [2]. Lee HS, et, al. Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa. Phytotherapy Research. 1998 May; 12(3): 212-214. [3]. Ko JS, et, al. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Med. 2002 Dec;68(12):1131-3. [Content Brief] [4]. Adams M, et, al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8. [Content Brief]