2. Academic Validation
  3. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase

  • Arch Pharm Res. 2002 Dec;25(6):817-9. doi: 10.1007/BF02976997.
Dae Keun Kim 1
Affiliations

Affiliation

  • 1 College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
PMID: 12510831 DOI: 10.1007/BF02976997
Abstract

In the course of screening Korean Natural Products for acetylcholinesterase (AChE) inhibitory activity, it was found that a methanolic extract of the aerial parts of Corydalis incisa (Papaveraceae) showed significant inhibitory effects on AChE. Corynoline isolated from this plant inhibited AChE activity in a dose-dependent manner, and the IC50 value of corynoline was 30.6 microM. The AChE inhibitory activity of corynoline was reversible and noncompetitive.

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