2. Academic Validation
  3. Non-antibiotic antibacterial activity of dodecyl gallate

Non-antibiotic antibacterial activity of dodecyl gallate

  • Bioorg Med Chem. 2003 Feb 20;11(4):573-80. doi: 10.1016/s0968-0896(02)00436-4.
Isao Kubo 1,  Ken ichi Fujita,  Ken ichi Nihei,  Noriyoshi Masuoka
Affiliations

Affiliation

  • 1 Department of Environmental Science, Policy and Management, University of California, CA 94720-3112, Berkeley, USA. ikubo@uclink4.berkeley.edu
PMID: 12538022 DOI: 10.1016/s0968-0896(02)00436-4
Abstract

Dodecyl (C(12)) gallate (3,4,5-trihydroxybenzoate) (1) was found to possess Antibacterial activity specifically against Gram-positive bacteria, in addition to its potent antioxidant activity. The time-kill curve study indicates that this amphipathic gallate exhibits bactericidal activity against methicillin resistant Staphylococcus aureus (MRSA) strains. Dodecyl (lauryl) gallate inhibited oxygen consumption in whole cells and oxidation of NADH in membrane preparation. The Antibacterial activity of this gallate comes in part from its ability to inhibit the membrane respiratory chain. As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend in part on the hydrophobic portion of the molecule.

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