2. Academic Validation
  3. Antifungal constituents of the stem bark of Bridelia retusa

Antifungal constituents of the stem bark of Bridelia retusa

  • Phytochemistry. 2003 Feb;62(4):637-41. doi: 10.1016/s0031-9422(02)00623-4.
Lalith Jayasinghe 1,  B M Mallika Kumarihamy,  K H R Nishantha Jayarathna,  N W M Gayathri Udishani,  B M Ratnayake Bandara,  Noriyuki Hara,  Yoshinori Fujimoto
Affiliations

Affiliation

  • 1 Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka. lalith@ifs.ac.lk
PMID: 12560039 DOI: 10.1016/s0031-9422(02)00623-4
Abstract

Antifungal activity guided fractionation of solvent extracts of the stem bark of Bridelia retusa of the family Euphorbiaceae against Cladosporium cladosporioides, furnished new bisabolane Sesquiterpenes, (E)-4-(1,5-dimethyl-3-oxo-1-hexenyl)benzoic acid, (E)-4-(1,5-dimethyl-3-oxo-1,4-hexadienyl) benzoic acid, (R)-4-(1,5-dimethyl-3-oxo-4-hexenyl)benzoic acid and (-)-isochaminic acid, together with the known (R)-4-(1,5-dimethyl-3-oxohexyl)benzoic acid (ar-todomatuic acid), 5-allyl-1,2,3-trimethoxybenzene (elemicin), (+)-sesamin and 4-isopropylbenzoic acid (cumic acid). All these compounds showed fungicidal activity on TLC bioautography method at very low concentrations except elemicin.

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