2. Academic Validation
  3. The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo

The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo

  • Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(4):204-6.
Q M Wang 1,  Y C Ni,  Y Q Xu,  S H Ha,  Y Cai
Affiliations

Affiliation

  • 1 Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025.
PMID: 12567659
Abstract

Objective: To investigate the in vitro and in vivo schizontocidal activity of daphnetin.

Methods: Schizontocidal activity of daphnetin was tested using an in vitro assay based on the routine in vitro cultivation of P. falciparum FCC1 strain. The in vivo antimalarial effects of daphnetin at various dosages were assessed in mice infected with P. b. erghei ANKA according to "4-day suppress assay".

Results: In vitro, daphnetin exhibited potent schizontocidal activity comparable to chloroquine(CQ) at the dose range of 1-10 mumol/L. In vivo, 50 or 100 mg/kg.d-1 x 4 d daphnetin i.g. and 10, 50 or 100 mg/kg.d-1 x 4 d dephnetin i.p. showed antimalarial efficacy comparable to CQ 10 mg/kg.d-1 x 4 d i.g. in mice infected with P. berghei ANKA, evaluated by both the reduction rate of parasitemia on D4 and the average surviving days in 30 days.

Conclusion: Daphnetin displays certain schizontocidal activity both in vitro and in vivo.

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