2. Academic Validation
  3. Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines

Cytotoxic activity of 6-alkynyl- and 6-alkenylpurines

  • Bioorg Med Chem Lett. 2003 Mar 10;13(5):877-80. doi: 10.1016/s0960-894x(03)00011-8.
Anders Bråthe 1,  Lise-Lotte Gundersen,  Jon Nissen-Meyer,  Frode Rise,  Bjørn Spilsberg
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Oslo, PO Box 1033, Blindern, 0315 Oslo, Norway.
PMID: 12617912 DOI: 10.1016/s0960-894x(03)00011-8
Abstract

6-Alkynyl- and 6-alkenylpurines have been screened for cytotoxic activity against a human chronic myelogenous leukemia cell line; K-562 cells using a [(3)H]-thymidine incorporation assay. Most alkynes displayed cytotoxicity comparable to, or better than, the known Anticancer drugs 6-mercaptopurine and fludarabine. The 6-alkenylpurines, which are promising plant growth stimulators and 15-lipoxygenase inhibitors, exhibited only low toxicity.

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