2. Academic Validation
  3. Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities

  • Bioorg Med Chem Lett. 2003 Feb 24;13(4):609-12. doi: 10.1016/s0960-894x(02)01041-7.
Sang-sup Jew 1,  Boon-saeng Park,  Doo-yeon Lim,  Myoung Goo Kim,  In Kwon Chung,  Joo Hee Kim,  Chung Il Hong,  Joon-Kyum Kim,  Hong-Jun Park,  Jun-Hee Lee,  Hyeung-geun Park
Affiliations

Affiliation

  • 1 Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, South Korea. ssjew@plaza.snu.ac.kr
PMID: 12639541 DOI: 10.1016/s0960-894x(02)01041-7
Abstract

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro Telomerase inhibitory activity and quite significant in vivo tumor suppression activity.

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