2. Academic Validation
  3. The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons

The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons

  • Science. 2003 May 23;300(5623):1288-91. doi: 10.1126/science.1082588.
Galit Lev-Maor 1,  Rotem Sorek,  Noam Shomron,  Gil Ast
Affiliations

Affiliation

  • 1 Department of Human Genetics and Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
PMID: 12764196 DOI: 10.1126/science.1082588
Abstract

Alu repetitive elements can be inserted into mature messenger RNAs via a splicing-mediated process termed exonization. To understand the molecular basis and the regulation of the process of turning intronic Alus into new exons, we compiled and analyzed a data set of human exonized Alus. We revealed a mechanism that governs 3' splice-site selection in these exons during alternative splicing. On the basis of these findings, we identified mutations that activated the exonization of a silent intronic Alu.

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