2. Academic Validation
  3. Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria

  • J Mol Biol. 2003 Jun 20;329(5):853-7. doi: 10.1016/s0022-2836(03)00528-x.
Jan Piwowarski 1,  Pawel Grzechnik,  Andrzej Dziembowski,  Aleksandra Dmochowska,  Michal Minczuk,  Piotr P Stepien
Affiliations

Affiliation

  • 1 Department of Genetics, Warsaw University and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawinskiego 5A, 02-106 Warsaw, Poland.
PMID: 12798676 DOI: 10.1016/s0022-2836(03)00528-x
Abstract

The human gene encoding a polynucleotide phosphorylase (hPNPase) has been recently identified as strongly up-regulated in two processes leading to irreversible arrest of cell division: progeroid senescence and terminal differentiation. Here, we demonstrate that the hPNPase is localized in mitochondria. Our finding suggests the involvement of mitochondrial RNA metabolism in cellular senescence.

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