2. Academic Validation
  3. In vitro trypanocidal activity of triterpenes from miconia species

In vitro trypanocidal activity of triterpenes from miconia species

  • Planta Med. 2003 May;69(5):470-2. doi: 10.1055/s-2003-39719.
Wilson Roberto Cunha,  Camila Martins,  Daniele da Silva Ferreira,  Antonio Eduardo Miller Crotti,  Norberto Peporine Lopes,  Sérgio Albuquerque
PMID: 12802734 DOI: 10.1055/s-2003-39719
Abstract

The bioassay-guided fractionation of methylene chloride extracts of Miconia fallax DC. and Miconia stenostachya DC. led to the isolation of five triterpene acids. The Triterpenes ursolic acid, oleanolic acid and gypsogenic acid were active against blood trypomastigote forms of Trypanosoma cruzi. In contrast, the acetyl and methyl ester derivatives were not found to potentiate the trypanocidal activity. These results suggest the importance of the polar groups for activity.

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