2. Academic Validation
  3. Cytotoxic diterpenes from Scoparia dulcis

Cytotoxic diterpenes from Scoparia dulcis

  • J Nat Prod. 2003 Jul;66(7):958-61. doi: 10.1021/np020356j.
Monira Ahsan 1,  S K N Islam,  Alexander I Gray,  William H Stimson
Affiliations

Affiliation

  • 1 Department of Pharmacy and Institute of Nutrition and Food Science, University of Dhaka, Dhaka-1000, Bangladesh. monira@smpt.udhaka.net
PMID: 12880314 DOI: 10.1021/np020356j
Abstract

Four new labdane-derived diterpenes, iso-dulcinol (1), 4-epi-scopadulcic acid B (2), dulcidiol (4), and scopanolal (5), together with two known diterpenes, dulcinol/scopadulciol (3) and scopadiol (6), were isolated from the aerial parts of Scoparia dulcis. The structures were determined by extensive NMR studies. The crude extracts as well as the pure diterpenes showed cytotoxicity against a panel of six human stomach Cancer cell lines.

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