2. Academic Validation
  3. Study of stereoselective synthesis of (+/-)-neocnidilide

Study of stereoselective synthesis of (+/-)-neocnidilide

  • J Asian Nat Prod Res. 2003 Sep;5(3):165-9. doi: 10.1080/1028602031000066870.
Xiao-Zhen Jiao 1,  Ping Xie,  Lian-Suo Zu,  Xiao-Tian Liang
Affiliations

Affiliation

  • 1 Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
PMID: 12931848 DOI: 10.1080/1028602031000066870
Abstract

Neocnidilide 1, isolated from Apium graveleues L (Umbelliferae), has shown activity to inhibit the growth of mycotoxin-producing fungi. An efficient method for the synthesis of the racemic neocnidilide by the stereoselective reaction of hemiacetal 6 with n-BuMgBr has been developed.

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