Lignans, phenylpropanoids and polyacetylenes from Chaerophyllum aureum L. (Apiaceae)

Sub-aerial parts of Chaerophyllum aureum L. yielded two polyacetylenes, falcarinol (1), falcarindiol (2), three Lignans, namely nemerosin (3), deoxypodorhizone (4), deoxypodo-phyllotoxin (5), two Phenylpropanoids, 1'-hydroxymyristicin (6) and its angeloyl ester (7). Compounds 6 and 7 were isolated for the first time from plant material and their structures were elucidated by means of extensive 1- and 2-dimensional NMR spectroscopy and high resolution mass spectrometry. In bioautographic tests on TLC plates the dichloromethane extract showed a significant antimicrobial activity. Falcarindiol was identified as the main active principle whereas the Phenylpropanoids and Lignans showed no activity.