2. Academic Validation
  3. Molecular cloning and binding properties of the human type II activin receptor

Molecular cloning and binding properties of the human type II activin receptor

  • Biochem Biophys Res Commun. 1992 Apr 15;184(1):310-6. doi: 10.1016/0006-291x(92)91194-u.
C J Donaldson 1,  L S Mathews,  W W Vale
Affiliations

Affiliation

  • 1 Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.
PMID: 1314589 DOI: 10.1016/0006-291x(92)91194-u
Abstract

A full-length cDNA for the type II human activin receptor was cloned by hybridization from a human testis cDNA library. The sequence encodes a 513 amino acid protein that is 99% identical, at the amino acid level, with the mouse type II activin receptor. The type II human activin receptor consists of an extracellular domain that specifically binds Activin A with a Kd of 360 pM, a single-membrane spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity.

Figures