2. Academic Validation
  3. A protein of the endoplasmic reticulum involved early in polypeptide translocation

A protein of the endoplasmic reticulum involved early in polypeptide translocation

  • Nature. 1992 May 7;357(6373):47-52. doi: 10.1038/357047a0.
D Görlich 1,  E Hartmann,  S Prehn,  T A Rapoport
Affiliations

Affiliation

  • 1 Max-Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.
PMID: 1315422 DOI: 10.1038/357047a0
Abstract

To identify components of the mammalian endoplasmic reticulum involved in the translocation of secretory proteins, crosslinking and reconstitution methods were combined. A multispanning abundant membrane glycoprotein was found which is in proximity to nascent chains early in translocation. In reconstituted proteoliposomes, this protein is stimulatory or required for the translocation of secretory proteins.

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