2. Academic Validation
  3. New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure

New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure

  • Agric Biol Chem. 1990 Nov;54(11):2883-7.
H Osada 1,  M Uramoto,  J Uzawa,  K Kajikawa,  K Isono
Affiliations

Affiliation

  • 1 RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
PMID: 1368648
Abstract

Antibacteriophage Antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.

Figures
Products