2. Academic Validation
  3. An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

  • FEBS Lett. 1992 Mar 30;300(2):162-6. doi: 10.1016/0014-5793(92)80187-l.
F C Bange 1,  T Flohr,  U Buwitt,  E C Böttger
Affiliations

Affiliation

  • 1 Medical School Hannover, Institute for Medical Microbiology, Germany.
PMID: 1373391 DOI: 10.1016/0014-5793(92)80187-l
Abstract

Interferon gamma induces expression of a protein termed IFP 53 according to its molecular weight of 53 kDa. IFP 53 shows significant sequence homology to rabbit peptide chain release factor as well as to bovine tryptophanyl-tRNA synthetase. IFP 53 has been shown to possess release factor activity for the UGA stop codon. We demonstrate here, by using a recombinant IFP 53 fusion protein, that IFP 53 tryptophanylates tRNA. These data indicate that IFP 53 is a protein with two activities: peptide chain termination and aminoacylation.

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