2. Academic Validation
  3. Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor

Inhibition of membrane currents and rises of intracellular Ca2+ in PC12 cells by CGS 9343B, a calmodulin inhibitor

  • Eur J Pharmacol. 1992 Jun 5;226(2):183-5. doi: 10.1016/0922-4106(92)90182-u.
R Neuhaus 1,  B F Reber
Affiliations

Affiliation

  • 1 Department of Pharmacology, University of Bern, Switzerland.
PMID: 1379190 DOI: 10.1016/0922-4106(92)90182-u
Abstract

The Calmodulin inhibitor 1,3-dihydro-1-[1-((4-methyl-4H,6H-pyrrolo[1,2-a]-[4,1]benzoxazepin - 4-yl)methyl)-4-piperidinyl]-2H-benzimidazol-2-one maleate (CGS 9343B) caused a reversible block of voltage-activated Ca2+, Na+, and K+ currents in differentiated rat pheochromocytoma (PC12) cells. The drug also inhibited nicotinic acetylcholine receptor (nAChR) channel currents but not inward currents evoked by extracellular ATP. Depolarization-induced intracellular Ca2+ transients were almost completely inhibited in growth cones and cell bodies by CGS 9343B. Our results suggest actions of CGS 9343B on ion fluxes unrelated to Calmodulin inhibition.

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