2. Academic Validation
  3. Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

Gerfelin, a novel inhibitor of geranylgeranyl diphosphate synthase from Beauveria felina QN22047. I. Taxonomy, fermentation, isolation, and biological activities

  • J Antibiot (Tokyo). 2003 Jul;56(7):617-21. doi: 10.7164/antibiotics.56.617.
Satoko Zenitani 1,  Satoshi Tashiro,  Kazutoshi Shindo,  Koji Nagai,  Kenichi Suzuki,  Masaya Imoto
Affiliations

Affiliation

  • 1 Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
PMID: 14513904 DOI: 10.7164/antibiotics.56.617
Abstract

A new compound, gerfelin, was isolated from a culture broth of Beauveria felina QN22047. It was purified by column chromatography on silica gel and by HPLC. Gerfelin has the molecular formula C15H14O6. It inhibited synthesis of geranylgeranyl diphosphate, which was mediated by recombinant human geranylgeranyl diphosphate synthase (hGGPP synthase) in vitro. The inhibitory pattern of gerfelin was noncompetitive against isopentenyl diphosphate, and uncompetitive against farnesyl diphosphate.

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