2. Academic Validation
  3. Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells

Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3665-8. doi: 10.1016/j.bmcl.2003.08.023.
Sangtae Oh 1,  In Howa Jeong,  Woon-Seob Shin,  Seokjoon Lee
Affiliations

Affiliation

  • 1 Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
PMID: 14552753 DOI: 10.1016/j.bmcl.2003.08.023
Abstract

Thioacetal artemisinin derivatives, in particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10alpha-mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at the concentration level of 1 microM.

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