2. Academic Validation
  3. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas

Anti-tumor activities of decursinol angelate and decursin from Angelica gigas

  • Arch Pharm Res. 2003 Sep;26(9):727-30. doi: 10.1007/BF02976682.
Sanghyun Lee 1,  Yeon Sil Lee,  Sang Hoon Jung,  Kuk Hyun Shin,  Bak-Kwang Kim,  Sam Sik Kang
Affiliations

Affiliation

  • 1 Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
PMID: 14560921 DOI: 10.1007/BF02976682
Abstract

The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.

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