1. Academic Validation
  2. Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia

Pangelin, an antimycobacterial coumarin from Ducrosia anethifolia

  • Planta Med. 2003 Oct;69(10):956-9. doi: 10.1055/s-2003-45109.
Michael Stavri 1 K T Mathew Franz Bucar Simon Gibbons
Affiliations

Affiliation

  • 1 Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, U.K.
Abstract

The aerial parts of Ducrosia anethifolia afforded the monoterpene glucoside 8-debenzoylpaeoniflorin ( 1) and the prenylated furanocoumarin pangelin [5-[2"( R)-hydroxy-3"-methyl-3"-butenyloxy]furocoumarin] ( 2). Their structures were determined by extensive 1- and 2-dimensional NMR studies. Compound 2 demonstrated activity against a panel of fast growing mycobacteria, namely Mycobacterium fortuitum, M. aurum, M. phlei and M. smegmatis and minimum inhibitory concentration (MIC) values ranged from 64 - 128 microg/mL. Whilst compounds 1 and 2 have previously been reported as an antihyperglycaemic component from Paeonia lactiflora, and as a constituent of Angelica pancici, respectively, this is the first report of the full (1)H- and (13)C-NMR data for these Natural Products.

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