2. Academic Validation
  3. Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines

Three new oleanane-type triterpenes from Ludwigia octovalvis with cytotoxic activity against two human cancer cell lines

  • J Nat Prod. 2004 Jan;67(1):91-3. doi: 10.1021/np030267m.
Chi-I Chang 1,  Ching-Chuan Kuo,  Jang-Yang Chang,  Yueh-Hsiung Kuo
Affiliations

Affiliation

  • 1 Graduate Institute of Biotechnology, National Pingtung University of Science and Technology, Pingtung, Taiwan 912, Republic of China.
PMID: 14738395 DOI: 10.1021/np030267m
Abstract

Three new oleanane-type Triterpenes, (23Z)-coumaroylhederagenin (1), (23E)-coumaroylhederagenin (2), and (3Z)-coumaroylhederagenin (3), together with two known triterpene acids, oleanolic acid and ursolic acid, have been isolated from the whole plant of Ludwigia octovalvis, and their structures have been elucidated by spectroscopic methods. All three new Triterpenes showed significant cytotoxicity against two human tumor cell lines, namely, oral epidermoid carcinoma KB and colorectal carcinoma HT29, and gave IC(50) values in the range 1.2-3.6 microM.

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