2. Academic Validation
  3. Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones

  • Bioorg Med Chem Lett. 2004 Mar 8;14(5):1235-7. doi: 10.1016/j.bmcl.2003.12.046.
Heesoon Lee 1,  Sungmoon Cho,  Kwon Namgoong,  Jae-Kyung Jung,  Jungsook Cho,  Sung-Il Yang
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea. medchem@chungbuk.ac.kr
PMID: 14980672 DOI: 10.1016/j.bmcl.2003.12.046
Abstract

A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human Cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 Cancer cell line.

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