2. Academic Validation
  3. Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult

Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult

  • Bioorg Med Chem Lett. 2004 Mar 8;14(5):1287-9. doi: 10.1016/j.bmcl.2003.12.041.
Darrick S H L Kim 1,  Jin Yung Kim
Affiliations

Affiliation

  • 1 Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. dkim@curxcel@com
PMID: 14980683 DOI: 10.1016/j.bmcl.2003.12.041
Abstract

Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.

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