Lakoochins A and B, new antimycobacterial stilbene derivatives from Artocarpus lakoocha

J Nat Prod. 2004 Mar;67(3):485-6. doi: 10.1021/np030429e.

Apirak Puntumchai ¹, Prasat Kittakoop, Shuleewan Rajviroongit, Saovaluk Vimuttipong, Kittisak Likhitwitayawuid, Yodhathai Thebtaranonth

Affiliations

Affiliation

1 Department of Chemistry, Faculty of Science, Mahidol University, Thailand.

PMID: 15043440 DOI: 10.1021/np030429e

Abstract

Two new stilbene derivatives, lakoochins A (1) and B (2), were isolated from the roots of Artocarpus lakoocha. The structures of 1 and 2 were elucidated by analysis of their spectral data. Lakoochins A (1) and B (2) exhibited antimycobacterial activity with the respective MIC values of 12.5 and 50 microg/mL. While 1 was cytotoxic against the BC (breast Cancer) cell line (IC(50) 6.1 microg/mL) but inactive (at 20 microg/mL) toward KB (nasopharyngeal carcinoma) cells, compound 2 possessed cytotoxicity against the BC and KB cell lines with IC(50) values of 3.1 and 6.1 microg/mL, respectively.

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